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KMID : 0363220170550090606
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Korean Journal of Dermatology
2017 Volume.55 No. 9 p.606 ~ p.609
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A Case of Rapidly Progressive Kaposi’s Sarcoma Induced by Systemic Corticosteroid Therapy
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Lee Ho-Yeol
Woo Cheong-Ha
Park Hai-Jin
Haw Sik
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Abstract
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Kaposi’s sarcoma (KS) is a vascular neoplasm originating from vascular and lymphatic endothelial cells. Iatrogenic KS mainly develops in organ transplant patients or after receiving immunosuppressive therapy. An 81-year-old man presented with multiple dark-purplish nodules, plaques, and patches on the right leg for 3 weeks. Previously, the patient was treated with prednisolone 10∼30 mg/day for chronic obstructive pulmonary disease for 3 months, and percutaneous transluminal angioplasty was performed 1 month previously for the treatment of peripheral arterial occlusive disease. A biopsy specimen of the nodule showed closely packed spindle cells forming slit-like vascular structures, which were consistent with KS. Despite the dosage reduction of prednisolone for treatment, the skin lesions progressed aggressively throughout the entire body, and the patient died after 5 months. We report a case of iatrogenic prednisolone-associated KS rapidly progressing to the entire body shortly thereafter.
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KEYWORD
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Kaposi sarcoma, Iatrogenic disease, Glucocorticoids
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